Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

J. Jansen, Willemijn; Ossenkoppele, Rik; L. Knol, Dirk; M. Tijms, Betty; Scheltens, Philip; R.J. Verhey, Frans; Jelle Visser, Pieter; Aalten, Pauline; Aarsland, Dag; Alcolea, Daniel; Alexander, M; S. Almdahl, Ina; E. Arnold, Steven; Baldeiras, Inês; Barthel, Henryk; N.M. van Berckel, Bart; Bibeau, Kristen; Blennow, Kaj; J. Brooks, David; A. van Buchem, Mark; Camus, Vincent; Cavedo, Enrica; Chen, Kewei; Chételat, Gaël; D. Cohen, Ann; Drzezga, Alexander; Engelborghs, Sebastiaan; M. Fagan, Anne; Fladby, Tormod; Fleisher, Adam; M. van der Flier, Wiesje; Ford, Lisa; Förster, Stefan; Fortea, Juan; Foskett, Nadia; Steen Frederiksen, Kristian; Freund‐Levi, Yvonne; B. Frisoni, Giovanni; Froelich, Lutz; Gabryelewicz, Tomasz; Dip Gill, Kiran; Gkatzima, Olymbia; Gómez‐Tortosa, Estrella; Forrest Gordon, Mark; Grimmer, Timo; Hampel, Harald; Hausner, Lucrezia; Hellwig, Sabine; Herukka, Sanna‐Kaisa; Hildebrandt, Helmut; Ishihara, Lianna; Ivanoiu, Adrian; J. Jagust, William; Johannsen, Peter; Kandimalla, Ramesh; Kapaki, Elisabeth; Klimkowicz‐Mrowiec, Aleksandra; E. Klunk, William; Köhler, Sebastian; Koglin, Norman; Kornhuber, Johannes; G. Kramberger, Milica; Van Laere, Koen; Landau, Susan; Young Lee, Dong; J. de Leon, Mony; Lisetti, Viviana; Lleó, Alberto; Madsen, Karine; Maier, Wolfgang; Marcusson, Jan; Mattsson, Niklas; de Mendonça, Alexandre; Meulenbroek, Olga; T. Meyer, Philipp; A. Mintun, Mark; Mok, Vincent; Luís Molinuevo, José; M. Møllergård, Hanne; C. Morris, John; Mroczko, Barbara; Van der Mussele, Stefan; L. Na, Duk; B. Newberg, Andrew; Nordberg, Agneta; Nordlund, Arto; Novak, Gerald; P. Paraskevas, George; Parnetti, Lucilla; Perera, Gayan; Peters, Oliver; Popp, Julius; Prabhakar, Sudesh; D. Rabinovici, Gil; H.G.B. Ramakers, Inez; Rami, Lorena; R. Oliveira, Catarina; O. Rinne, Juha; M. Rodrigue, Karen; Rodríguez‐Rodríguez, Eloy; M. Roe, Catherine; Rot, Uroš; C. Rowe, Christopher; Rüther, Eckart; Sabri, Osama; Sánchez‐Juan, Pascual; Santana, Isabel; Sarazin, Marie; Schröder, Johannes; Schütte, Christin; Won Seo, Sang; Soetewey, Femke; Soininen, Hilkka; Spiru, Luiza; Struyfs, Hanne; E. Teunissen, Charlotte; Tsolaki, Magda; Vandenberghe, Rik; M. Verbeek, Marcel; L. Villemagne, Victor; J. B. Vos, Stephanie; J.C. van Waalwijk van Doorn, Linda; Waldemar, Gunhild; Wallin, Anders; K. Wallin, Åsa; Wiltfang, Jens; A. Wolk, David; Zboch, Marzena; Zetterberg, Henrik

doi:10.1001/jama.2015.4668

Public

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

Published in JAMA • May 19, 2015

Authors:

Willemijn J. Jansen

Rik Ossenkoppele

Dirk L. Knol

Abstract

IMPORTANCE: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. O...

Subject

Medicine

Dementia

Amyloid (mycology)

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