Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

L. Jongbloed, Sarah; J. Kassianos, Andrew; McDonald, Kylie; J. Clark, Georgina; Ju, Xinsheng; E. Angel, Catherine; J. Chen, Chun‐Jen; Rod Dunbar, P.; Wadley, Robert; Jeet, Varinder; Vulink, Annelie; N.J. Hart, Derek; J. Radford, Kristen

doi:10.1084/jem.20092140

Public

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Published in The Journal of Experimental Medicine • May 17, 2010

Authors:

Sarah L. Jongbloed

Andrew J. Kassianos

Kylie McDonald

Abstract

The characterization of human dendritic cell (DC) subsets is essential for the design of new vaccines. We report the first detailed functional analysis of the human CD141+ DC subset. CD141+ DCs are found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best sourc...

Subject

Cytotoxic T cell

Dendritic cell

Biology

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