T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

Daussy, Cécile; Faure, Fabrice; Mayol, Katia; Viel, Sébastien; Gasteiger, Georg; Charrier, Emily; Bienvenu, Jacques; Henry, Thomas; Debien, Emilie; Hasan, Uzma; Marvel, Jacqueline; Yoh, Keigyou; Takahashi, Satoru; Prinz, Immo; de Bernard, Simon; Buffat, Laurent; Walzer, Thierry

doi:10.1084/jem.20131560

Public

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

Published in The Journal of Experimental Medicine • Feb 10, 2014

Authors:

Cécile Daussy

Fabrice Faure

Katia Mayol

Abstract

Trail(+)DX5(-)Eomes(-) natural killer (NK) cells arise in the mouse fetal liver and persist in the adult liver. Their relationships with Trail(-)DX5(+) NK cells remain controversial. We generated a novel Eomes-GFP reporter murine model to address this question. We found that Eomes(-) NK cells are no...

Subject

Biology

Interleukin 12

Natural killer T cell

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