Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

D. Ahuja, Shama; Ashkin, David; Avendano, Monika; Banerjee, Rita; Bauer, Melissa; Bayona, J; C. Becerra, Mercedes; Benedetti, Andrea; Burgos, Marcos; Centis, Rosella; D. Chan, Eward; Chiang, Chen‐Yuan; Cox, Helen; D’Ambrosio, Lia; DeRiemer, Kathryn; Huy Dung, Nguyen; A. Enarson, Donald; Falzon, Dennis; Flanagan, Katherine; Flood, Jennifer; L. Garcia-Garcia, Maria; R. Gandhi, Neel; Granich, Reuben; Hollm-Delgado, Maria-Graciela; H. Holtz, Timothy; D. Iseman, Michael; G. Jarlsberg, Leah; Keshavjee, Salmaan; Kim, Hye-Ryoun; Koh, Won‐Jung; Lancaster, Joey; Lange, Christoph; C.M. de Lange, Wiel; Leimane, Vaira; Chiu Leung, Chi; Li, Jiehui; Menzies, Dick; Battista Migliori, Giovanni; P. Mishustin, Sergey; D. Mitnick, Carole; Narita, Masahiro; O'Riordan, Philly; Pai, Madhukar; Palmero, Domingo; Park, Seung-Kyu; Pasvol, Geoffrey; M. Peña, José; Pérez-Guzmán, Carlos; Imelda Quelapio, Maria; Ponce‐de‐León, Alfredo; Riekstiņa, Vija; Robert, J.; Royce, Sarah; Simon Schaaf, H.; J. Seung, Kwonjune; Shah, Lena; Sun Shim, Tae; Shin, Sonya; Shiraishi, Yuji; Sifuentes‐Osornio, José; Sotgiu, Giovanni; Strand, Matthew; Tabarsi, Payam; E. Tupasi, Thelma; van Altena, Robert; van der Walt, Martie; S. van der Werf, Tjip; H. Vargas, Mario; Viiklepp, Pirett; Westenhouse, Janice; Wai Yew, Wing; Yim, Jae‐Joon; Group for Meta-Analysis of Individual Patient Data in MDR-TB, Collaborative

doi:10.1371/journal.pmed.1001300

Public

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Published in PLoS Medicine • Aug 28, 2012

Authors:

Shama D. Ahuja

David Ashkin

Monika Avendano

Abstract

BACKGROUND: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of the type, number, and duration of drugs used to treat MDR-TB. METHODS AND FINDIN...

Subject

Medicine

Ethionamide

Odds ratio

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