Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Seddiki, Nabila; Santner‐Nanan, Brigitte; Martinson, Jeff; Zaunders, John; C. Sasson, Sarah; Landay, Alan; J. Solomon, Michael; Selby, Warwick; I. Alexander, Stephen; Nanan, Ralph; D. Kelleher, Anthony; Fazekas de St Groth, Barbara

doi:10.1084/jem.20060468

Public

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Published in The Journal of Experimental Medicine • Jul 3, 2006

Authors:

Nabila Seddiki

Brigitte Santner‐Nanan

Jeff Martinson

Abstract

Abnormalities in CD4(+)CD25(+)Foxp3(+) regulatory T (T reg) cells have been implicated in susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However, phenotypic and functional assessment of human T reg cells has been hampered by difficulty in distinguishing between CD25-expre...

Subject

IL-2 receptor

Interleukin-7 receptor

FOXP3

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