Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

Street, John; Bao, Min; Deguzman, Leo; Bunting, Stuart; Peale, Franklin; Ferrara, Napoleone; Steinmetz, Hope; M. Hoeffel, J.; L. Cleland, Jeffrey; L. Daugherty, Ann; van Bruggen, Nicholas; P. Redmond, H.; A.D. Carano, Richard; Filvaroff, Ellen

doi:10.1073/pnas.152324099

Public

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

Published in Proceedings of the National Academy of Sciences • Jul 12, 2002

Authors:

John Street

Min Bao

Leo Deguzman

Abstract

Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repa...

Subject

Intramembranous ossification

Endochondral ossification

Angiogenesis

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