Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer

U. Lin, Nancy; Dièras, Véronique; Paul, Devchand; Lossignol, Dominique; Christodoulou, Christos; Stemmler, Hans‐Joachim; Roché, Henri; C. Liu, Minetta; Greil, Richard; Ciruelos, Eva; Loibl, Sibylle; Gori, Stefania; Wardley, Andrew; A. Yardley, Denise; Brufsky, Adam; L. Blum, Joanne; D. Rubin, Stephen; Dharan, B.; Steplewski, Klaudia; Zembryki, Denise; Oliva, Cristina; Roychowdhury, Debasish; Paoletti, Paolo; P. Winer, Eric

doi:10.1158/1078-0432.ccr-08-1080

Public

Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer

Published in Clinical Cancer Research • Feb 15, 2009

Authors:

Nancy U. Lin

Véronique Dièras

Devchand Paul

Abstract

PURPOSE: Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS) progression after cranial radiation is extremely limited and represents a major clinical challenge. Lapatinib, an epidermal growth factor rec...

Subject

Lapatinib

Capecitabine

Medicine

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