Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

Enzo, Nisoli,; Emilio, Clementi,; Clara, Paolucci,; Valeria, Cozzi,; Cristina, Tonello,; Clara, Sciorati,; Renata, Bracale,; Alessandra, Valerio,; Maura, Francolini,; Salvador, Moncada,; Michele O, Carruba,

doi:10.1126/science.1079368

Public

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

Published in Science (New York, N.Y.) • Feb 7, 2003

Authors:

Nisoli, Enzo

Clementi, Emilio

Paolucci, Clara

Abstract

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma...

Subject

3T3 Cells

8-Bromo Cyclic Adenosine Monophosphate

Adipocytes

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