Cell-Specific and pH-Activatable Rubyrin-Loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy against Cancer

Tian, Jiangwei; Ding, Lin; Xu, Haijun; Shen, Zhen; Ju, Huangxian; Li, Jia; Bao, Lei; Yu, Jun‐Sheng

doi:10.1021/ja408286k

Public

Cell-Specific and pH-Activatable Rubyrin-Loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy against Cancer

Published in Journal of the American Chemical Society • Dec 2, 2013

Authors:

Jiangwei Tian

Lin Ding

Haijun Xu

Abstract

Spatiotemporal control of singlet oxygen ((1)O2) release is a major challenge for photodynamic therapy (PDT) against cancer with high therapeutic efficacy and minimum side effects. Here a selenium-rubyrin (NMe2Se4N2)-loaded nanoparticle functionalized with folate (FA) was designed and synthesized as...

Subject

Chemistry

Singlet oxygen

Photodynamic therapy

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