Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Quirke, Andrew; B. Lugli, Elena; Wegner, Natalia; C Hamilton, Bart; Charles, P.; Chowdhury, Muslima; Jimmy Ytterberg, A.; A. Zubarev, Roman; Potempa, Jan; Culshaw, Shauna; Guo, Yonghua; A. Fisher, Benjamin; M. Thiele, Geoffrey; R. Mikuls, Ted; J Venables, Patrick

doi:10.1136/annrheumdis-2012-202726

Public

Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Published in Annals of the Rheumatic Diseases • Mar 6, 2013

Authors:

Andrew Quirke

Elena B. Lugli

Natalia Wegner

Abstract

BACKGROUND: Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA. P gingivalis is apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylargini...

Subject

Citrullination

Porphyromonas gingivalis

Citrulline

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