The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Gerken, Thomas; A. Girard, Christophe; Loraine Tung, Yi‐Chun; J. Webby, Celia; Saudek, Vladimı́r; S. Hewitson, Kirsty; S.H. Yeo, Giles; McDonough, M.A.; L. Cunliffe, Sharon; A. McNeill, Luke; Galvanovskis, Juris; Rorsman, Patrik; Robins, Peter; Prieur, Xavier; P. Coll, Anthony; Ma, Marcella; Jovanović, Z; Sadaf Farooqi, I.; Sedgwick, Barbara; Barroso, Inês; Lindahl, Tomas; P. Ponting, Chris; M. Ashcroft, Frances; O’Rahilly, Stephen; J. Schofield, Christopher

doi:10.1126/science.1151710

Public

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Published in Science • Nov 8, 2007

Authors:

Thomas Gerken

Christophe A. Girard

Yi‐Chun Loraine Tung

Abstract

Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)-...

Subject

Demethylation

Nucleic acid

FTO gene

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