Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

Bihorac, Azra; S. Chawla, Lakhmir; Shaw, Andrew; Al‐Khafaji, Ali; Davison, Danielle; E. DeMuth, George; L. Fitzgerald, Robert; N. Gong, Michelle; D. Graham, Derrel; J. Gunnerson, Kyle; Heung, Michael; A. Jortani, Saeed; C. Kleerup, Eric; L. Koyner, Jay; Krell, Kenneth; L. LeTourneau, Jennifer; Lissauer, Matthew; R. Miner, James; Bryant Nguyen, H.; Ortega, Luís; H. Self, Wesley; Sellman, Richard; Shi, Jing; A. Straseski, Joely; E. Szalados, James; T. Wilber, Scott; G. Walker, Michael; Wilson, Jason; G. Wunderink, Richard; L. Zimmerman, Janice; A. Kellum, John

doi:10.1164/rccm.201401-0077oc

Public

Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

Published in American Journal of Respiratory and Critical Care Medicine • Feb 21, 2014

Authors:

Azra Bihorac

Lakhmir S. Chawla

Andrew Shaw

Abstract

RATIONALE: We recently reported two novel biomarkers for acute kidney injury (AKI), tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), both related to G1 cell cycle arrest. OBJECTIVES: We now validate a clinical test for urinary [TIMP-2]·[IGFBP...

Subject

Medicine

Acute kidney injury

Internal medicine

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