Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Postmus, Iris; Trompet, Stella; Deshmukh, Harshal; R. Barnes, Michael; Li, Xiaohui; R. Warren, Helen; I. Chasman, Daniel; Zhou, Kaixin; J. Arsenault, Benoît; A. Donnelly, Louise; L. Wiggins, Kerri; L. Avery, Christy; J. Griffin, Paula; Feng, QiPing; D. Taylor, Kent; Li, Guo; S. Evans, Daniel; V. Smith, Albert; E. de Keyser, Catherine; D. Johnson, Andrew; J. M. de Craen, Anton; J. Stott, David; M. Buckley, Brendan; Ford, Ian; G. J. Westendorp, Rudi; Eline Slagboom, P.; Sattar, Naveed; B. Munroe, Patricia; Sever, Peter; Poulter, Neil; Stanton, Alice; C. Shields, Denis; OʼBrien, Eoin; Shaw‐Hawkins, Sue; Chen, Yu; A. Nickerson, Deborah; D. Smith, Joshua; Dubé, Marie‐Pierre; Matthijs Boekholdt, S.; Kees Hovingh, G.; J.P. Kastelein, John; McKeigue, Paul; Betteridge, John; Neil, Andrew; N. Durrington, Paul; S. F. Doney, Alex; Carr, Fiona; P. Morris, Andrew; I. McCarthy, Mark; Groop, Leif; Ahlqvist, Emma; C. Bis, Joshua; Rice, Kenneth; L. Smith, Nicholas; Lumley, Thomas; A. Whitsel, Eric; Stürmer‎, Til; Boerwinkle, Eric; S. Ngwa, Julius; J. O’Donnell, Christopher; S. Vasan, Ramachandran; Wei, Wei‐Qi; A. Wilke, Russell; Liu, Ching‐Ti; Sun, Fangui; Guo, Xiuqing; R. Heckbert, Susan; S. Post, Wendy; Sotoodehnia, Nona; M. Arnold, Alice; M. Stafford, Jeanette; Ding, Jingzhong; M. Herrington, David; B. Kritchevsky, Stephen; Eiríksdóttir, Guðný; J. Launer, Leonore; B. Harris, Tamara; Y. Chu, Audrey; Giulianini, Franco; MacFadyen, Jean; J. Barratt, Bryan; Nyberg, Fredrik; H. Stricker, Bruno; G. Uitterlinden, André; Hofman, Albert; Rivadeneira, Fernando; Emilsson, Valur; H. Franco, Oscar; M. Ridker, Paul; Guðnason, Vilmundur; Liu, Ching‐Ti; C. Denny, Joshua; M. Ballantyne, Christie; I. Rotter, Jerome; Adrienne Cupples, L.; M. Psaty, Bruce; N. A. Palmer, Colin; Tardif, Jean‐Claude; M. Colhoun, Helen; A. Hitman, G.; M. Krauss, Ronald; Wouter Jukema, J.; J. Caulfield, Mark; Donnelly, Peter; Barroso, Inês; M. Blackwell, Jenefer; Bramon, Elvira; A. Brown, Matthew; P. Casas, Juan; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; S. Markus, Hugh; G. Mathew, Christopher; N. A. Palmer, Colin; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen; C. Trembath, Richard; C. Viswanathan, Ananth; Wood, Nicholas; and Analysis Group, Data; C. A. Spencer, Chris; Band, Gavin; Bellenguez, Céline; L. Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; D. Pearson, Richard; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Donnelly, Peter; Genotyping, Data QC and Informatics Group, DNA,; Langford, Cordelia; Hunt, Sarah; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; J. Bumpstead, Suzannah; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; T McCann, Owen; Liddle, Jennifer; Potter, Simon; Ravindrarajah, Rathi; Ricketts, Michelle; Waller, Matthew; A. Weston, Paul; Widaa, Sara; Whittaker, Pamela; Barroso, Ines; Deloukas, Panos; G. Mathew, Christopher; M. Blackwell, Jenefer; A. Brown, Matthew; Corvin, Aiden; I. McCarthy, Mark; C. A. Spencer, Chris

doi:10.1038/ncomms6068

Public

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Published in Nature Communications • Oct 28, 2014

Authors:

Iris Postmus

Stella Trompet

Harshal Deshmukh

Abstract

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...

Subject

Pharmacogenetics

Genome-wide association study

Ldl cholesterol

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