The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

Aiuti, Alessandro; J. Webb, Iain; C. Bleul, Conrad; A. Springer, Timothy; Carlos Gutierrez‐Ramos, José

doi:10.1084/jem.185.1.111

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The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

Published in The Journal of Experimental Medicine • Jan 1, 1997

Authors:

Alessandro Aiuti

Iain J. Webb

Conrad C. Bleul

Abstract

Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stromal cells. This is the first chemoattractant reported for human CD34+ progenitor cells. Concentrations of SDF-1 that elicit chemotaxis also i...

Subject

Progenitor cell

CD34

Biology

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