Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

A. Francis, Prudence; M. Regan, Meredith; F. Fleming, Gini; Láng, István; Ciruelos, Eva; Bellet, Meritxell; Bonnefoi, Hervé; Ángel Climent, Miguel; Antonio Da Prada, Gian; J. Burstein, Harold; Martino, Silvana; E. Davidson, Nancy; E. Geyer, Charles; Walley, Barbara; E. Coleman, Robert; Kerbrat, Pierre; Buchholz, Stefan; N. Ingle, James; P. Winer, Eric; Rabaglio, Manuela; Maibach, Rudolf; Ruepp, Barbara; Giobbie‐Hurder, Anita; N. Price, Karen; Colleoni, Marco; Viale, Giuseppe; S. Coates, Alan; Goldhirsch, Aron; D. Gelber, Richard

doi:10.1056/nejmoa1412379

Public

Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

Published in New England Journal of Medicine • Dec 11, 2014

Authors:

Prudence A. Francis

Meredith M. Regan

Gini F. Fleming

Abstract

BACKGROUND: Suppression of ovarian estrogen production reduces the recurrence of hormone-receptor-positive early breast cancer in premenopausal women, but its value when added to tamoxifen is uncertain. METHODS: We randomly assigned 3066 premenopausal women, stratified according to prior receipt or ...

Subject

Tamoxifen

Breast cancer

Medicine

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