Adjuvant ovarian suppression in premenopausal breast cancer.

PA, Francis; MM, Regan; GF, Fleming; I, Láng; E, Ciruelos; M, Bellet; HR, Bonnefoi; MA, Climent; Prada GA, Da; HJ, Burstein; S, Martino; NE, Davidson; CE Jr, Geyer; BA, Walley; R, Coleman; P, Kerbrat; S, Buchholz; JN, Ingle; EP, Winer; M, Rabaglio-Poretti; R, Maibach; B, Ruepp; A, Giobbie-Hurder; KN, Price; M, Colleoni; G, Viale; AS, Coates; A, Goldhirsch; RD, Gelber

doi:10.1056/nejmoa1412379

Public

Adjuvant ovarian suppression in premenopausal breast cancer.

Shared by NobleBlocks on Dec 11, 2014 • 12:00 AM UTC

Authors:

Francis PA

Regan MM

Fleming GF

Abstract

Background Suppression of ovarian estrogen production reduces the recurrence of hormone-receptor-positive early breast cancer in premenopausal women, but its value when added to tamoxifen is uncertain.Methods We randomly assigned 3066 premenopausal women, stratified according to prior receipt or non...

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