IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

Kurihara, Noriyoshi; R. Bertolini, Donald; Suda, Toshio; Akiyama, Yoshitsugu; David Roodman, G.

doi:10.4049/jimmunol.144.11.4226

Public

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

Shared by NobleBlocks on Jun 1, 1990 • 12:00 AM UTC

Authors:

Noriyoshi Kurihara

Donald R. Bertolini

Toshio Suda

Abstract

IL-6 enhances the differentiation of pluripotent hematopoietic stem cells but predominantly affects the differentiation of hematopoietic cells in the granulocyte-macrophage lineage. We have previously shown that multinucleated cells (MNC) with many features of the osteoclast phenotype form in long t...

Subject

Haematopoiesis

Osteoclast

Bone marrow

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