Essential and Instructive Roles of GATA Factors in Eosinophil Development

Hirasawa, Ryutaro; Shimizu, Ritsuko; Takahashi, Satoru; Osawa, Mitsujiro; Takayanagi, Shu; Kato, Yuko; Onodera, Masafumi; Minegishi, Naoko; Yamamoto, Masayuki; Fukao, Katashi; Taniguchi, Hideki; Nakauchi, Hiromitsu; Iwama, Atsushi

doi:10.1084/jem.20020170

Public

Essential and Instructive Roles of GATA Factors in Eosinophil Development

Published in The Journal of Experimental Medicine • Jun 3, 2002

Authors:

Ryutaro Hirasawa

Ritsuko Shimizu

Satoru Takahashi

Abstract

GATA transcription factors are major regulators of hematopoietic and immune system. Among GATA factors, GATA-1, GATA-2, and GATA-3 play crucial roles in the development of erythroid cells, hematopoietic stem, and progenitor cells, and T helper type 2 (Th2) cells, respectively. A high level of GATA-1...

Subject

Eosinophil

Haematopoiesis

Cell biology

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