Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene

R. Pearson, Ewan; F. Boj, Sylvia; Steele, Anna; Barrett, Timothy; Stals, Karen; Hamilton‐Shield, Julian; Ellard, Sian; Ferrer, Jorge; T. Hattersley, Andrew

doi:10.1371/journal.pmed.0040118

Public

Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene

Published in PLoS Medicine • Mar 29, 2007

Authors:

Ewan R. Pearson

Sylvia F. Boj

Anna Steele

Abstract

BACKGROUND: Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with diabetes and in congenital hyperinsulinaemia is mediated by increased foetal insulin...

Subject

HNF1A

Fetal macrosomia

Congenital hyperinsulinism

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