The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

A. Anis, Nabil; C. Berry, Stephen; Burton, N.R.; Lodge, David

doi:10.1111/j.1476-5381.1983.tb11031.x

Public

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

Published in British Journal of Pharmacology • Jun 1, 1983

Authors:

Nabil A. Anis

Stephen C. Berry

N.R. Burton

Abstract

The interaction of two dissociative anaesthetics, ketamine and phencyclidine, with the responses of spinal neurones to the electrophoretic administration of amino acids and acetylcholine was studied in decerebrate or pentobarbitone-anaesthetized cats and rats. Both ketamine and phencyclidine selecti...

Subject

Phencyclidine

Kainate receptor

Chemistry

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