Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis

Chen, Chia‐Yen; Ping, Yueh‐Hsin; Lee, Hsin‐Chen; Chen, Kuan-Hsuan; Lee, Yuan-Ming; Chan, Yu-Juin; Lien, Te‐Cheng; Jap, Tjin‐Shing; Lin, Chi-Hung; Kao, Lung‐Sen; Arthur Chen, Yi‐Ming

doi:10.1086/519166

Public

Open Reading Frame 8a of the Human Severe Acute Respiratory Syndrome Coronavirus Not Only Promotes Viral Replication but Also Induces Apoptosis

Published in The Journal of Infectious Diseases • Jun 29, 2007

Authors:

Chia‐Yen Chen

Yueh‐Hsin Ping

Hsin‐Chen Lee

Abstract

BACKGROUND: A unique genomic difference between human and civet severe acute respiratory syndrome coronaviruses (SARS-CoVs) is that the former has a deletion of 29 nucleotides from open reading frame (orf) 8a' that results in the generation of orf8a and orf8b. The objectives of the present study wer...

Subject

Apoptosis

Transfection

Open reading frame

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