Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Nonaka, Takashi; Masuda‐Suzukake, Masami; Arai, Tetsuaki; Hasegawa, Yoko; Akatsu, Hiroyasu; Obi, Tomokazu; Yoshida, Mari; Murayama, Shigeo; Mann, David; Akiyama, Haruhiko; Hasegawa, Masato

doi:10.1016/j.celrep.2013.06.007

Public

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Published in Cell Reports • Jul 1, 2013

Authors:

Takashi Nonaka

Masami Masuda‐Suzukake

Tetsuaki Arai

Abstract

TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS). Here, we report the characterization of prion-like properties of aggregated TDP-43 prepared from diseased brains. Whe...

Subject

Frontotemporal lobar degeneration

Ubiquitin

Amyotrophic lateral sclerosis

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!