Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease

M. Gutiérrez, Orlando; Isakova, Tamara; P. Rhee, Eugene; Shah, Anand; Holmes, Julie; Collerone, Gina; Ju[Combining Diaeresis]ppner, Harald; Wolf, Myles

doi:10.1681/asn.2005010052

Public

Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease

Published in Journal of the American Society of Nephrology • May 26, 2005

Authors:

Orlando M. Gutiérrez

Tamara Isakova

Eugene P. Rhee

Abstract

Hyperphosphatemia, calcitriol deficiency, and secondary hyperparathyroidism (SHPT) are common complications of chronic kidney disease (CKD). Fibroblast growth factor-23 (FGF-23) is a novel phosphaturic hormone that also inhibits renal 1alpha-hydroxylase activity and thus may be involved in the patho...

Subject

Hyperphosphatemia

Calcitriol

Fibroblast growth factor 23

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