Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Sidransky, E.; A. Nalls, Mike; Aasly, Jan; Aharon‐Peretz, J.; Annesi, Grazia; Reis Barbosa, Egberto; Bar‐Shira, Anat; Berg, Daniela; Brás, José; Brice, Alexis; Chen, Chien‐Ming; N. Clark, Lorraine; Condroyer, Christel; Valeria De Marco, Elvira; Dürr, Alexandra; J. Eblan, Michael; Fahn, S; J. Farrer, Matthew; Fung, Hon‐Chung; Gan‐Or, Ziv; Gasser, Thomas; Gershoni‐Baruch, Ruth; Giladi, Nir; Griffith, Alida; Gurevich, Tanya; Januário, Cristina; Kropp, Peter; E. Lang, Anthony; Lee‐Chen, Guey‐Jen; Lesage, Suzanne; Marder, K.; F. Mata, Ignácio; Mirelman, Anat; Mitsui, Jun; Mizuta, Ikuko; Nicoletti, Giuseppe; R. Oliveira, Catarina; Ottman, Ruth; Orr‐Urtreger, Avi; V. Pereira, Lygia; Quattrone, Aldo; Rogaeva, Ekaterina; Rolfs, A.; Rosenbaum, Hanna; Rozenberg, Roberto; Samii, Ali; Samaddar, T.; Schulte, Claudia; Sharma, Manu; Singleton, Andrew; Spitz, Mariana; Tan, Eng‐King; Tayebi, N.; Toda, Tatsushi; R. Troiano, A.; Tsuji, Shoji; Wittstock, Matthias; G. Wolfsberg, Tyra; Wu, Yih‐Ru; P. Zabetian, Cyrus; Zhao, Yirui; G. Ziegler, Shira

doi:10.1056/nejmoa0901281

Public

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Published in New England Journal of Medicine • Oct 21, 2009

Authors:

E. Sidransky

Mike A. Nalls

Jan Aasly

Abstract

BACKGROUND: Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patie...

Subject

Glucocerebrosidase

Medicine

Odds ratio

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