Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia

L. Cummings, Jeffrey; G. Lyketsos, Constantine; R. Peskind, Elaine; P. Porsteinsson, Anton; Mintzer, Jacobo; W. Scharre, Douglas; E. De La Gándara, José; Agronin, Marc; S. Davis, Charles; Nguyen, Uyen; Shin, Paul; N. Tariot, Pierre; Siffert, João

doi:10.1001/jama.2015.10214

Public

Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia

Published in JAMA • Sep 22, 2015

Authors:

Jeffrey L. Cummings

Constantine G. Lyketsos

Elaine R. Peskind

Abstract

IMPORTANCE: Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE: To assess the efficacy, safety, and tolerability of dextromethorphan hydrobromide-quinidine sulfate for Alzheimer disease-related agitation. DESIGN, SETTING, AND PARTICIPANTS: Ph...

Subject

Dextromethorphan

Medicine

Placebo

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