Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Falini, Brunangelo; Mecucci, Cristina; Tiacci, Enrico; Alcalay, Myriam; Rosati, Roberto; Pasqualucci, Laura; La Starza, Roberta; Diverio, Daniela; Colombo, Emanuela; Santucci, Antonella; Bigerna, Barbara; Pacini, Roberta; Pucciarini, Alessandra; Liso, Arcangelo; Vignetti, Marco; Fazi, Paola; Meani, Natalia; Pettirossi, Valentina; Saglio, Giuseppe; Mandelli, Franco; Lo‐Coco, Francesco; Giuseppe Pelicci, Pier; F. Martelli, Massimo

doi:10.1056/nejmoa041974

Public

Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Published in New England Journal of Medicine • Jan 19, 2005

Authors:

Brunangelo Falini

Cristina Mecucci

Enrico Tiacci

Abstract

BACKGROUND: Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein. METHODS: We used immunohistochemical methods to study ...

Subject

Nucleophosmin

Cytoplasm

Cancer research

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