Inactivating<i>KISS1</i>Mutation and Hypogonadotropic Hypogonadism

Kemal Topaloğlu, A.; A. Tello, Javier; Damla Kotan, Leman; Nuri Özbek, Mehmet; Bertan Yılmaz, Mehmet; Erdoğan, Şeref; Gürbüz, Fatih; Temiz, Fatih; P. Millar, Robert; Yüksel, Bilgin

doi:10.1056/nejmoa1111184

Public

InactivatingKISS1Mutation and Hypogonadotropic Hypogonadism

Published in New England Journal of Medicine • Feb 15, 2012

Authors:

A. Kemal Topaloğlu

Javier A. Tello

Leman Damla Kotan

Abstract

Gonadotropin-releasing hormone (GnRH) is the central regulator of gonadotropins, which stimulate gonadal function. Hypothalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release. Inactivating mutations in the genes encoding the human kisspeptin receptor (KISS1R, formerly called...

Subject

Kisspeptin

Hypogonadotropic hypogonadism

Neurokinin B

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