Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis

M. Ruiz‐Palacios, Guillermo; Pérez‐Schael, Irene; Raúl Velázquez, F.; Abate, Héctor; Breuer, Thomas; Ann Costa Clemens, Sue; Cheuvart, Brigitte; Espinoza, Félix; Gillard, Paul; L. Innis, Bruce; Cervantes, Yolanda; C. Linhares, Alexandre; López, Pío; Macías-Parra, Mercedes; Ortega‐Barría, Eduardo; Richardson, Vesta; Maribel Rivera-Medina, Doris; Rivera, Luis; Salinas, Belén; Pavía-Ruz, Noris; Salmerón, Jorge; Rüttimann, Ricardo; Carlos Tinoco, Juan; Rubio, Pilar; Nuñez, Ernesto; Lourdes Guerrero, M.; Pablo Yarzábal, Juan; Damaso, Silvia; Tornieporth, Nadia; Sáez‐Llorens, Xavier; Vergara, Rodrigo; Vesikari, Timo; Bouckenooghe, Alain; Clemens, Ralf; De Vos, Béatrice; O’Ryan, Miguel

doi:10.1056/nejmoa052434

Public

Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis

Published in New England Journal of Medicine • Jan 4, 2006

Authors:

Guillermo M. Ruiz‐Palacios

Irene Pérez‐Schael

F. Raúl Velázquez

Abstract

BACKGROUND: The safety and efficacy of an attenuated G1P[8] human rotavirus (HRV) vaccine were tested in a randomized, double-blind, phase 3 trial. METHODS: We studied 63,225 healthy infants from 11 Latin American countries and Finland who received two oral doses of either the HRV vaccine (31,673 in...

Subject

Medicine

Rotavirus vaccine

Rotavirus

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