Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation

Although the cellular functions of TSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor suppressor gene are associated with tumor development in lymphangioleiomyomatosis (LAM). We found that ribosomal protein S6 (S6), which exerts translational control of protein... View More