Validating novel tau positron emission tomography tracer <scp>[F‐18]‐AV‐1451 (T807)</scp> on postmortem brain tissue

Marquié, Marta; D. Normandin, Marc; Vanderburg, Charles; Costantino, Isabel; Bien, Elizabeth; G. Rycyna, Lisa; E. Klunk, William; A. Mathis, Chester; D. Ikonomović, Miloš; L. Debnath, Manik; Vasdev, Neil; C. Dickerson, Bradford; N. Gomperts, Stephen; H. Growdon, John; A. Johnson, Keith; P. Frosch, Matthew; T. Hyman, Bradley; Gómez‐Isla, Teresa

doi:10.1002/ana.24517

Public

Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue

Published in Annals of Neurology • Sep 7, 2015

Authors:

Marta Marquié

Marc D. Normandin

Charles Vanderburg

Abstract

OBJECTIVE: To examine region- and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau-containing lesions, and to determine whether there ...

Subject

Frontotemporal lobar degeneration

Progressive supranuclear palsy

Pathology

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