Statins Protect Human Aortic Smooth Muscle Cells From Inorganic Phosphate-Induced Calcification by Restoring Gas6-Axl Survival Pathway

Son, Bo‐Kyung; Kozaki, Koichi; Iijima, Katsuya; Eto, Masato; Kojima, Taro; Ota, Hidetaka; Senda, Yuka; Maemura, Koji; Nakano, Toru; Akishita, Masahiro; Ouchi, Yasuyoshi

doi:10.1161/01.res.0000218859.90970.8d

Public

Statins Protect Human Aortic Smooth Muscle Cells From Inorganic Phosphate-Induced Calcification by Restoring Gas6-Axl Survival Pathway

Published in Circulation Research • Mar 24, 2006

Authors:

Bo‐Kyung Son

Koichi Kozaki

Katsuya Iijima

Abstract

Vascular calcification is clinically important in the development of cardiovascular disease. It is reported that hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) inhibited vascular calcification in several clinical trials. However, the mechanism is poorly understood. Rece...

Subject

GAS6

Vascular smooth muscle

Calcification

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