Antileishmanial Activity of an Indole Alkaloid from<i>Peschiera australis</i>

Carlo Morais Oliveira Bertassoni Delorenzi, Jan; Attias, Márcia; Rocha Gattass, Cerli; Guimarães Andrade, Marcelo; M. Rezende, Cláudia; da Cunha Pinto, Ângelo; Teresinha Henriques, Amélia; Chequer Bou‐Habib, Dumith; M. Saraiva, Elvira

doi:10.1128/aac.45.5.1349-1354.2001

Public

Antileishmanial Activity of an Indole Alkaloid fromPeschiera australis

Published in Antimicrobial Agents and Chemotherapy • May 1, 2001

Authors:

Jan Carlo Morais Oliveira Bertassoni Delorenzi

Márcia Attias

Cerli Rocha Gattass

Abstract

In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania amazonensis, a causative agent of cutaneous leishmaniasis in the New World. In a bioassay-guided chemical fractio...

Subject

Amastigote

Indole alkaloid

Alkaloid

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