Somatic mutations of the <i>APC</i> gene in colorectal tumors: mutation cluster region in the <i>APC</i> gene

Mori, Yasuo; Nagse, Hiroki; Ando, Hiroshi; Horii, Akira; Ichii, Shigetoshi; Nakatsuru, Shuichi; Aoki, Takahisa; Miki, Yoshio; Mori, Takesada; Nakamura, Yusuke

doi:10.1093/hmg/1.4.229

Public

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

Published in Human Molecular Genetics • Jan 1, 1992

Authors:

Yasuo Mori

Hiroki Nagse

Hiroshi Ando

Abstract

We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutat...

Subject

Biology

Frameshift mutation

Exon

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