Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.

Di Stefano, Antonino; Caramori, Gaetano; Barczyk, Adam; Vicari, Chiara; Brun, Paola; Zanini, Andrea; Cappello, Francesco; Garofano, Elvira; Padovani, Anna; Contoli, Marco; Casolari, Paolo; L Durham, Andrew; Fan Chung, Kian; J Barnes, Peter; Papi, Alberto; Adcock, Ian; Balbi, Bruno

doi:10.1136/thoraxjnl-2012-203062

Public

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.

Shared by NobleBlocks on Jun 1, 2014 • 12:00 AM UTC

Authors:

Antonino Di Stefano

Gaetano Caramori

Adam Barczyk

Abstract

BACKGROUND: In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. OBJECTIVES: To investigate the activation of i...

Subject

COPD Pathology

Innate Immunity

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