Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock

Tili, Esmerina; Michaille, Jean‐Jacques; Cimino, Amelia; Costinean, Stefan; Dan Dumitru, Calin; Adair, Brett; Fabbri, Muller; Alder, Hannes; Gong Liu, Chang; A. Calin, George; M. Croce, Carlo

doi:10.4049/jimmunol.179.8.5082

Public

Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock

Published in The Journal of Immunology • Oct 1, 2007

Authors:

Esmerina Tili

Jean‐Jacques Michaille

Amelia Cimino

Abstract

We report here that miR-155 and miR-125b play a role in innate immune response. LPS stimulation of mouse Raw 264.7 macrophages resulted in the up-regulation of miR-155 and down-regulation of miR-125b levels. The same changes also occurred when C57BL/6 mice were i.p. injected with LPS. Furthermore, t...

Subject

RIPK1

Tumor necrosis factor alpha

Lipopolysaccharide

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