Randomized Trial of Induction Chemotherapy With Cisplatin and 5-Fluorouracil With or Without Docetaxel for Larynx Preservation

Pointreau, Y.; Garaud, P.; Chapet, S.; Sire, C.; Tuchais, C.; Tortochaux, J.; Faivre, Sandrine; Guerrif, S.; Alfonsi, M.; Calais, G.

doi:10.1093/jnci/djp007

Public

Randomized Trial of Induction Chemotherapy With Cisplatin and 5-Fluorouracil With or Without Docetaxel for Larynx Preservation

Published in JNCI Journal of the National Cancer Institute • Mar 24, 2009

Authors:

Y. Pointreau

P. Garaud

S. Chapet

Abstract

BACKGROUND: Chemotherapy with cisplatin (P) and 5-fluorouracil (F) followed by radiotherapy in patients who respond to chemotherapy is an alternative to total laryngectomy for patients with locally advanced larynx and hypopharynx cancer. Data suggest that docetaxel (T) may add to the efficacy of PF....

Subject

Medicine

Docetaxel

Laryngectomy

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