A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

Young, Gregory; Keizer, Joel

doi:10.1073/pnas.89.20.9895

Public

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

Published in Proceedings of the National Academy of Sciences • Oct 15, 1992

Authors:

Gregory Young

Joel Keizer

Abstract

Relying on quantitative measurements of Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the endoplasmic reticulum, we construct a simplified kinetic model to describe the properties of this channel. Selecting rate constants to fit key kinetic and equilibrium data...

Subject

Endoplasmic reticulum

Inositol

Inositol trisphosphate receptor

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