Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Hirota, Seiichi; Isozaki, Koji; Moriyama, Y; Hashimoto, Koji; Nishida, Toshirou; Ishiguro, Shingo; Kawano, Kiyoshi; Hanada, Masato; Kurata, A; Takeda, Masashi; Muhammad Tunio, Ghulam; Matsuzawa, Yūji; Kanakura, Yuzuru; Shinomura, Yasuhisa; Kitamura, Yukihiko

doi:10.1126/science.279.5350.577

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Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

Published in Science • Jan 23, 1998

Authors:

Seiichi Hirota

Koji Isozaki

Y Moriyama

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular etiology and cellular origin are unknown. Sequencing of c-kit complementary DNA, which encodes a proto-oncogenic receptor tyrosine kinase (KIT), from five GISTs revealed m...

Subject

Interstitial cell of Cajal

Proto-Oncogene Proteins c-kit

Stem cell factor

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