Gain-of-Function Mutations of c-
            <i>kit</i>
            in Human Gastrointestinal Stromal Tumors

Hirota, Seiichi; Isozaki, Koji; Moriyama, Yasuhiro; Hashimoto, Koji; Nishida, Toshirou; Ishiguro, Shingo; Kawano, Kiyoshi; Hanada, Masato; Kurata, Akihiko; Takeda, Masashi; Muhammad Tunio, Ghulam; Matsuzawa, Yuji; Kanakura, Yuzuru; Shinomura, Yasuhisa; Kitamura, Yukihiko

doi:10.1126/science.279.5350.577

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Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

Shared by NobleBlocks on Jan 23, 1998 • 12:00 AM UTC

Authors:

Seiichi Hirota

Koji Isozaki

Yasuhiro Moriyama

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular etiology and cellular origin are unknown. Sequencing of c- kit complementary DNA, which encodes a proto-oncogenic receptor tyrosine kinase (KIT), from five GISTs revealed ...

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