Corneal Abnormalities in<i>Pax6</i><sup>+/−</sup>Small Eye Mice Mimic Human Aniridia-Related Keratopathy

Ramaesh, Thaya; Martin Collinson, J.; Ramaesh, Kanna; H. Kaufman, Matthew; D. West, John; Dhillon, Baljean

doi:10.1167/iovs.02-0576

Public

Corneal Abnormalities inPax6+/−Small Eye Mice Mimic Human Aniridia-Related Keratopathy

Published in Investigative Ophthalmology & Visual Science • Apr 25, 2003

Authors:

Thaya Ramaesh

J. Martin Collinson

Kanna Ramaesh

Abstract

PURPOSE: To investigate corneal abnormalities in heterozygous Pax6(+/Sey-Neu) (Pax6(+/-), small eye) mice and compare them with aniridia-related keratopathy in PAX6(+/-) patients. METHODS: Fetal and postnatal corneal histopathology, adult corneal thickness, and the distribution of K12-immunostained ...

Subject

PAX6

Aniridia

Corneal epithelium

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