Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease

Nishimoto, Norihiro; Kanakura, Yuzuru; Aozasa, Katsuyuki; Johkoh, Takeshi; Nakamura, Minoru; Nakano, Shuji; Nakano, Nobuaki; Ikeda, Yasuo; Sasaki, Takeshi; Nishioka, Kiyoshi; Hara, Masamichi; Taguchi, Hirokuni; Kimura, Yukihiko; Kato, Yoshiro; Asaoku, Hideki; Kumagai, Shunichi; Kodama, Fumio; Nakahara, Hideko; Hagihara, Keisuke; Yoshizaki, Kazuyuki; Kishimoto, Tadamitsu

doi:10.1182/blood-2004-12-4602

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Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease

Published in Blood • Jul 5, 2005

Authors:

Norihiro Nishimoto

Yuzuru Kanakura

Katsuyuki Aozasa

Abstract

Multicentric Castleman disease (MCD) is an atypical lymphoproliferative disorder characterized by systemic lymphadenopathy and constitutional inflammatory symptoms. Dysregulated overproduction of interleukin-6 is responsible for the clinical abnormalities. This multicenter prospective study was unde...

Subject

Medicine

Internal medicine

Gastroenterology

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