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Comparative Efficacy and Distribution of Lipid Formulations of Amphotericin B in ExperimentalCandida albicansInfection of the Central Nervous System

Published in The Journal of Infectious Diseases • Jul 1, 2000

Authors:

Andreas H. Groll

Neelam Giri

Vidmantas Petraitis

Abstract

The central nervous system (CNS) distribution and antifungal efficacy of all 4 approved formulations of amphotericin B (AmB) were investigated in a rabbit model of hematogenous Candida albicans meningoencephalitis. Treatment with AmB deoxycholate (1 mg/kg/day) or liposomal AmB (5 mg/kg/day) yielded ...

Subject

Candida albicans

Amphotericin B

Minimum inhibitory concentration

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