Distinctive expression and function of four <i>GSDM</i> family genes (<i>GSDMA‐D</i>) in normal and malignant upper gastrointestinal epithelium

Saeki, Norihisa; Usui, Takebumi; Aoyagi, Kazuhiko; Ho Kim, Dal; Sato, Megumi; Mabuchi, Tomoko; Yanagihara, Kazuyoshi; Ogawa, Kenji; Sakamoto, Hiromi; Yoshida, Teruhiko; Sasaki, Hiroki

doi:10.1002/gcc.20636

Public

Distinctive expression and function of four GSDM family genes (GSDMA‐D) in normal and malignant upper gastrointestinal epithelium

Published in Genes Chromosomes and Cancer • Dec 2, 2008

Authors:

Norihisa Saeki

Takebumi Usui

Kazuhiko Aoyagi

Abstract

Gasdermin (GSDM or GSDMA), expressed in the upper gastrointestinal tract but frequently silenced in gastric cancers (GCs), regulates apoptosis of the gastric epithelium. It has three human homologs, GSDMB, GSDMC, and GSDMD (GSDM family) and they are considered to be involved in the regulation of epi...

Subject

Oncogene

Biology

Epithelium

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