Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding.

C Taggart, Clifford; Cryan, Sally-Ann; Weldon, Sinead; Gibbons, Aileen; M Greene, Catherine; Kelly, Emer; Boon Low, Teck; J O'neill, Shane; G McElvaney, Noel

doi:10.1084/jem.20050768

Public

Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding.

Shared by NobleBlocks on Dec 19, 2005 • 12:00 AM UTC

Authors:

Clifford C Taggart

Sally-Ann Cryan

Sinead Weldon

Abstract

Secretory leucoprotease inhibitor (SLPI) is a nonglycosylated protein produced by epithelial cells. In addition to its antiprotease activity, SLPI has been shown to exhibit antiinflammatory properties, including down-regulation of tumor necrosis factor alpha expression by lipopolysaccharide (LPS) in...

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