Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion during Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers

A. Nauck, Michael; M. Heimesaat, Markus; Behle, Kai; J. Holst, Jens; Nauck, Markus; Ritzel, Robert; Hüfner, M.; Schmiegel, Wolff

doi:10.1210/jcem.87.3.8355

Public

Effects of Glucagon-Like Peptide 1 on Counterregulatory Hormone Responses, Cognitive Functions, and Insulin Secretion during Hyperinsulinemic, Stepped Hypoglycemic Clamp Experiments in Healthy Volunteers

Published in The Journal of Clinical Endocrinology & Metabolism • Mar 1, 2002

Authors:

Michael A. Nauck

Markus M. Heimesaat

Kai Behle

Abstract

Glucagon-like peptide 1 (GLP-1) and analogues are being evaluated as a new therapeutic principle for the treatment of type 2 diabetes. GLP-1 suppresses glucagon secretion, which could lead to disturbances of hypoglycemia counterregulation. This has, however, not been tested. Nine healthy volunteers ...

Subject

Endocrinology

Internal medicine

Glucagon

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