Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

Koivusalo, Mirkka; M. Welch, Christopher; Hayashi, Hisayoshi; C. Scott, Cameron; Kim, Moshe; Alexander, Todd; Touret, Nicolas; M. Hahn, Klaus; Grinstein, Sergio

doi:10.1083/jcb.200908086

Public

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

Published in The Journal of Cell Biology • Feb 15, 2010

Authors:

Mirkka Koivusalo

Christopher M. Welch

Hisayoshi Hayashi

Abstract

Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility to inhibitors of Na(+)/H(+) exchange. Yet, the functional relationship between Na(+)/H(+) exchange and macropinosome formation remains obscure. In A431 cells, stimulation by EGF simultaneously activated m...

Subject

Pinocytosis

Amiloride

Biology

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