Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

de Assis Silva Gomes, Juliana; M. G. Bahia‐Oliveira, Lilian; Otávio da Costa Rocha, Manoel; Assis Martins‐Filho, Olindo; Gazzinelli, G.; Corrêa‐Oliveira, Rodrigo

doi:10.1128/iai.71.3.1185-1193.2003

Public

Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

Published in Infection and Immunity • Feb 20, 2003

Authors:

Juliana de Assis Silva Gomes

Lilian M. G. Bahia‐Oliveira

Manoel Otávio da Costa Rocha

Abstract

The role of interleukin 10 (IL-10) and gamma interferon (IFN-gamma) on the development of pathology in human Chagas' disease was investigated. Two categories of patients, low and high producers of IFN-gamma, were identified based on the levels of secretion of this cytokine in the supernatant of peri...

Subject

Biology

Peripheral blood mononuclear cell

Immune system

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