Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains

V. Ulianov, Sergey; E. Khrameeva, Ekaterina; A. Gavrilov, Alexey; M. Flyamer, Ilya; Kos, Pavel; A. Mikhaleva, Elena; A. Penin, Aleksey; D. Logacheva, Maria; Imakaev, Maxim; V. Chertovich, Alexander; S. Gelfand, Mikhail; Y. Shevelyov, Yuri; V. Razin, Sergey

doi:10.1101/gr.196006.115

Public

Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains

Published in Genome Research • Oct 30, 2015

Authors:

Sergey V. Ulianov

Ekaterina E. Khrameeva

Alexey A. Gavrilov

Abstract

Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal folding that were subsequently linked to disease and gene regulation. In particular, Hi-C revealed that chromosomes of animals are organized into topologically associating domains (TADs), evolutionary conserv...

Subject

Chromatin

Biology

Nucleosome

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