Defining reliable disability outcomes in multiple sclerosis

Kalinčík, Tomáš; Cutter, Gary; Spelman, Tim; Jokubaitis, Vilija; Havrdová, Eva; Horáková, Dana; Trojano, María; Izquierdo, Guillermo; Girard, Marc; Duquette, Pierre; Prat, Alexandre; Lugaresi, Alessandra; Grand’Maison, François; Grammond, Pierre; Hupperts, Raymond; Oreja‐Guevara, Celia; Boz, Cavit; Pucci, Eugenio; Bergamaschi, Roberto; Lechner‐Scott, Jeannette; Alroughani, Raed; Van Pesch, Vincent; Iuliano, Gerardo; Fernández‐Bolaños, Ricardo; Ramo‐Tello, Cristina; Terzi, Murat; Slee, Mark; Spitaleri, Daniele; Verheul, Freek; Cristiano, Edgardo; Luis Sánchez-Menoyo, José; Fiol, Marcela; Gray, Orla; Antonio Cabrera-Gómez, José; Barnett, Michael; Butzkueven, Helmut

doi:10.1093/brain/awv258

Public

Defining reliable disability outcomes in multiple sclerosis

Published in Brain • Sep 10, 2015

Authors:

Tomáš Kalinčík

Gary Cutter

Tim Spelman

Abstract

Prevention of irreversible disability is currently the most important goal of disease modifying therapy for multiple sclerosis. The disability outcomes used in most clinical trials rely on progression of Expanded Disability Status Scale score confirmed over 3 or 6 months. However, sensitivity and st...

Subject

Concordance

Medicine

Expanded Disability Status Scale

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