M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Van Overmeire, Eva; Stijlemans, Benoı̂t; Heymann, Felix; Keirsse, Jiri; Morias, Yannick; Elkrim, Yvon; Brys, Lea; Abels, Chloé; Lahmar, Qods; Ergen, Can; Vereecke, Lars; Tacke, Frank; De Baetselier, Patrick; A. Van Ginderachter, Jo; Laoui, Damya

doi:10.1158/0008-5472.can-15-0869

Public

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

Published in Cancer Research • Nov 16, 2015

Authors:

Eva Van Overmeire

Benoı̂t Stijlemans

Felix Heymann

Abstract

Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate from Ly6C(hi) monocytes. However, the mechanisms regulating the abundance and phenotype of distinct TAM subsets remain unknown. Here, we inv...

Subject

Macrophage polarization

Major histocompatibility complex

Biology

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