The transcriptional landscape of age in human peripheral blood

J. Peters, Marjolein; Joehanes, Roby; C. Pilling, Luke; Schurmann, Claudia; N. Conneely, Karen; E. Powell, Joseph; Reinmaa, Eva; L. Sutphin, George; Zhernakova, Alexandra; Schramm, Katharina; A. Wilson, Yana; Kobes, Sayuko; Tukiainen, Taru; A. Nalls, Michael; Hernández, Dena; Cookson, Mark; Raphael Gibbs, J.; Hardy, John; Ramasamy, Adaikalavan; B. Zonderman, Alan; Dillman, Allissa; J. Traynor, Bryan; Smith, Colin; L. Longo, Dan; Trabzuni, Daniah; C. Troncoso, Juan; van der Brug, Marcel; E. Weale, Michael; M. O’Brien, Richard; Johnson, Robert; Walker, Robert; H. Zielke, Ronald; Arepalli, Sampath; Ryten, Mina; Singleton, Andrew; Ramos, Y.F.; H.H. Göring, Harald; Fornage, Myriam; Liu, Ching‐Ti; A. Gharib, Sina; E. Stranger, Barbara; L. De Jager, Philip; Aviv, Abraham; Levy, Daniel; M. Murabito, Joanne; J. Munson, Peter; Huan, Tianxiao; Hofman, Albert; G. Uitterlinden, André; Rivadeneira, Fernando; van Rooij, Jeroen; Stolk, Lisette; Broer, Linda; Verbiest, Michaël; Jhamai, Mila; Arp, Pascal; Metspalu, Andres; Tserel, Liina; Milani, Lili; J. Samani, Nilesh; Peterson, Pärt; Kasela, Silva; Codd, Veryan; Peters, Annette; Ward‐Caviness, Cavin; Herder, Christian; Waldenberger, Mélanie; Roden, Michael; Singmann, Paula; Zeilinger, Sonja; Illig, Thomas; Homuth, Georg; J. Grabe, Hans; Völzke, Henry; Steil, Leif; Kocher, Thomas; Murray, Anna; Melzer, David; Yaghootkar, Hanieh; Bandinelli, Stefania; K. Moses, Eric; W. Kent, Jack; E. Curran, Joanne; P. Johnson, Matthew; Williams‐Blangero, Sarah; Westra, Harm-Jan; F. McRae, Allan; A. Smith, Jennifer; L. R. Kardia, Sharon; Hovatta, Iiris; Perola, Markus; Ripatti, Samuli; Salomaa, Veikko; K. Henders, Anjali; G. Martin, Nicholas; K. Smith, Alicia; Mehta, Divya; B. Binder, Elisabeth; Maria Nylocks, K.; M. Kennedy, Elizabeth; Klengel, Torsten; Ding, Jingzhong; M. Suchy‐Dicey, Astrid; A. Enquobahrie, Daniel; A. Brody, Jennifer; I. Rotter, Jerome; Ida Chen, Yii‐Der; J. Houwing‐Duistermaat, Jeanine; Kloppenburg, M.; Eline Slagboom, P.; Helmer, Quinta; den Hollander, Wouter; Bean, Shannon; Raj, Towfique; Bakhshi, Noman; Wang, Qiao‐Ping; J. Oyston, Lisa; M. Psaty, Bruce; P. Tracy, Russell; W. Montgomery, Grant; T. Turner, Stephen; Blangero, John; Meulenbelt, Ingrid; J. Ressler, Kerry; Yang, Jian; Franke, Lude; Kettunen, Johannes; M. Visscher, Peter; Gregory Neely, G.; Korstanje, Ron; L. Hanson, Robert; Prokisch, Holger; Ferrucci, Luigi; Esko, Tõnu; Teumer, Alexander; B. J. van Meurs, Joyce; D. Johnson, Andrew

doi:10.1038/ncomms9570

Public

The transcriptional landscape of age in human peripheral blood

Published in Nature Communications • Oct 22, 2015

Authors:

Marjolein J. Peters

Roby Joehanes

Luke C. Pilling

Abstract

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify ...

Subject

Transcriptome

Epigenetics

DNA methylation

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