Gene essentiality and synthetic lethality in haploid human cells

A. Blomen, Vincent; Májek, Peter; T. Jae, Lucas; W. Bigenzahn, Johannes; Nieuwenhuis, Joppe; Staring, Jacqueline; Sacco, Roberto; R. van Diemen, Ferdy; Olk, Nadine; Stukalov, Alexey; Marceau, Caleb; Janssen, Hans; E. Carette, Jan; L. Bennett, Keiryn; Colinge, Jacques; Superti-Furga, Giulio; R. Brummelkamp, Thijn

doi:10.1126/science.aac7557

Public

Gene essentiality and synthetic lethality in haploid human cells

Shared by NobleBlocks on Nov 27, 2015 • 12:00 AM UTC

Authors:

Vincent A. Blomen

Peter Májek

Lucas T. Jae

Abstract

Zeroing in on essential human genes More powerful genetic techniques are helping to define the list of genes required for the life of a human cell. Two papers used the CRISPR genome editing system and a gene trap method in haploid human cells to screen for essential genes (see the Perspective by Boo...

Discussions